Join a Multicenter Study on Precision Exercise in Fibromyalgia 

(FIBROGENHIIT©)

FIBROGENHIIT is a randomized controlled clinical trial (RCT) developed at the Department of Medical Sciences and Public Health, University of Cagliari (Italy), under the coordination of Professor Myosotis Massidda, with the support of Fondazione di Sardegna. The study investigates the effects of personalized high-intensity interval training (HIIT) in patients with fibromyalgia within a precision medicine framework.

FIBROGENHIIT goes beyond a traditional exercise intervention. It represents an integrated “Exercise as Medicine” research platform, combining exercise physiology, autonomic regulation, genetic profiling, and environmental modulation (indoor vs outdoor) to deliver individualized therapeutic strategies.

The project challenges the conventional “one-size-fits-all” model of exercise prescription by introducing a mechanism-based, biologically informed, and data-driven approach, grounded in physiological phenotyping and gene × environment interactions.

A key innovation of FIBROGENHIIT is the integration of digital health and AI-ready infrastructure. The project is supported by a dedicated mobile application that enables real-time monitoring of training sessions (heart rate, HR recovery, symptoms), standardized data collection, and centralized database integration. This digital ecosystem is designed to support advanced analytics, including future AI-driven models for adaptive exercise prescription and clinical decision support.

By combining randomized clinical design, wearable sensor technology (Polar H10), mobile health solutions, and multi-level biomarker analysis, FIBROGENHIIT establishes a scalable, transferable, and clinically applicable framework for precision non-pharmacological medicine.

We invite leading international academic institutions, clinical centers, and research laboratories to join this expanding global network and contribute to the development of a multicenter precision exercise platform, positioned for competitive international funding and long-term scientific impact.

International Collaboration Opportunity for a

Precision Exercise Medicine Consortium

FIBROGENHIIT is not designed as a stand-alone study, but as the foundation of a global consortium in Precision Exercise Medicine for chronic pain.

Our objective is to bring together institutions with the scientific expertise, clinical capacity, and strategic vision to co-develop large-scale international research initiatives. This initiative aims to bridge the gap between clinical research, digital innovation, and real-world implementation in exercise-based therapies.

FIBROGENHIIT has been conceived as a consortium-ready, scalable platform, designed to support:

  • Multicenter randomized controlled trials

  • Gene × environment interaction modeling

  • Mechanism-based and personalized exercise prescription

  • Integration of digital monitoring (FIBROGENHIIT APP) and AI-ready data infrastructures

  • Development of precision lifestyle and non-pharmacological medicine frameworks

The platform is strategically positioned for participation in major international funding programs, including Horizon Europe and other global research initiatives, fostering high-impact collaborative research and long-term scientific advancement.

How to Join the

FIBROGENHIIT International Consortium

Institutions interested in joining the FIBROGENHIIT network are invited to become part of a collaborative, multicenter research ecosystem in Precision Exercise Medicine.

Partnership Model

The consortium is structured to ensure both scientific rigor and operational flexibility, allowing institutions to participate according to their expertise and infrastructure.

Partner institutions may contribute at different levels:

Core Universities and Clinical Partners

 

  • Recruitment and clinical management of patients

  • Implementation of the FIBROGENHIIT intervention protocol

  • Collection of DNA, physiological and clinical outcomes


 

Research & Methodology Partners

 

  • Contribution to data analysis, modeling, and interpretation

  • Development of gene × environment and mechanistic frameworks

  • Support for AI-driven analytics and predictive modeling


 

Technology & Innovation Partners

 

  • Integration of wearable technologies and digital health tools

  • Development of data platforms, dashboards, and AI solutions

  • Contribution to digital infrastructure and interoperability


 

What You Will Gain

  • Access to a standardized protocol

  • Integration into a high-level international research network

  • Opportunity to participate in multicenter publications

  • Co-development of international grant applications (e.g., Horizon Europe)

  • Access to a digital ecosystem (App + centralized database)

  • Visibility within the USSIC scientific community

Requirements

Participating institutions are expected to:

  • Obtain local ethical approval

  • Ensure adherence to the shared protocol

  • Contribute to high-quality data collection

  • Participate in coordination meetings and scientific activities

From Strategic Interest to Institutional Partnership.

FIBROGENHIIT is structured as a coordinated international research platform. To ensure methodological integrity, scientific coherence, and long-term consortium development, access to the intervention protocol is subject to a formal engagement process.

FIBROGENHIIT is not an open-distribution initiative; it is a strategically curated international research network built through selected institutional partnerships.

Step 1: Institutional Expression of Interest.

Submit your formal expression of interest to initiate a dialogue regarding potential collaboration with FIBROGENHIIT.

Step 2: Strategic Alignment Meeting.

A dedicated meeting to align strategic objectives and assess institutional synergy within the FIBROGENHIIT consortium framework.

Step 3: Controlled Access to the Protocol.

Following strategic alignment, controlled access will be granted to the FIBROGENHIIT implementation framework and research protocols.

Institutions joining at this stage become founding contributors to a global Precision Exercise Medicine platform, strategically positioned for competitive international funding, multicenter expansion, and long-term scientific leadership.

Website Project: https://www.fibrogenhiit.com/